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Updated: May 20, 2025

Author Spotlight: Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
Published on: May 26, 2023
[Antibiotic prophylaxis when taking corticosteroids]
Gabriel Hans1, Benedek Roska1, Mallory Moret Bochatay1
1Service de médecine interne et des soins intensifs, Groupement hospitalier de l'Ouest lémanique, 1260 Nyon.
Abstract:
Antibioprophylaxis in the setting of high-dose corticosteroid therapy is primarily indicated for the prevention of Pneumocystis jirovecii pneumonia (PJP), a potentially fatal infection in immunocompromised individuals. According to the American Thoracic Society (2010) and National Comprehensive Cancer Network (NCCN) guidelines (2024), prophylactic administration of co-trimoxazole is recommended only for patients who are immunocompromised and receiving corticosteroid therapy at doses ≥20 mg of prednisone equivalent per day for ≥28 days. Deviation from these guidelines may unnecessarily expose patients to serious and potentially life-threatening adverse effects of co-trimoxazole, such as agranulocytosis.
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