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Recent Developments and Future Perspectives in Magnetic Resonance Imaging and Computed Tomography Contrast Media
Thomas Frenzel1, Thomas Wels, Hubertus Pietsch
1Bayer AG, Radiology, Berlin, Germany (T.F., H.P., L.S., J.E.); Wels - Omnino Medico, Rotkreuz, Switzerland (T.W.); Bayer U.S. LLC, Indianola, PA (P.S.); and Department of Gynecology, Obstetrics and Reproductive Medicine, University Medical School of Saarland, Homburg/Saar, Germany (J.E.).
Investigative Radiology
|March 31, 2025
Summary
This review examines new computed tomography (CT) and magnetic resonance imaging (MRI) contrast agents, focusing on safety and clinical efficacy. It highlights advancements in iodinated agents, gadolinium-based agents, and emerging imaging techniques.
Area of Science:
- Radiology and Medical Imaging
- Pharmacology of Contrast Agents
Background:
- Contrast media are essential for diagnostic imaging with CT and MRI.
- Continuous development aims to improve efficacy and safety profiles.
Purpose of the Study:
- To review recent advancements in CT and MRI contrast media.
- To critically evaluate current trends and future directions in contrast agent development.
- To assess clinical efficacy and safety of new contrast agents.
Main Methods:
- Comprehensive literature review of advancements in CT and MRI contrast media over the last 5-8 years.
- Analysis of clinical efficacy and safety data.
- Focus on specific agent types including iodinated, gadolinium-based, iron oxide, and manganese-based agents.
Main Results:
- CT: General safety of iodinated contrast agents, impact on renal/thyroid function, contrast-enhanced mammography, and photon-counting CT outlook.
- MRI: Safety update, nephrogenic systemic fibrosis, brain gadolinium deposition, and new high-relaxivity agents (gadopiclenol, gadoquatrane).
- Emerging agents include targeted GBCAs, SPIONs, manganese-based agents, and glymphatic imaging.
Conclusions:
- Recent advancements offer improved diagnostic capabilities and safety profiles for CT and MRI contrast media.
- Newer agents and techniques like photon-counting CT and glymphatic imaging show significant promise.
- Ongoing research focuses on targeted delivery, enhanced relaxivity, and understanding long-term safety.
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