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Updated: May 10, 2025

Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica
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Epithelial cell extrusion at a glance.

Aline Grata1, Romain Levayer1

  • 1Department of Developmental and Stem Cell Biology, Institut Pasteur, Université de Paris Cité, CNRS UMR 3738, 25 rue du Dr. Roux, 75015 Paris, France.

Journal of Cell Science
|April 24, 2025
PubMed
Summary
This summary is machine-generated.

Epithelial cell extrusion removes cells while maintaining tissue seals. This process involves cytoskeletal and junctional remodeling, crucial for tissue repair, development, and disease.

Keywords:
ActomyosinApoptosisCaspasesCell extrusionCell–cell adhesionEpitheliumJunctions

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Area of Science:

  • Cell Biology
  • Tissue Engineering
  • Developmental Biology

Background:

  • Epithelial tissues require cell turnover for robustness and plasticity.
  • Maintaining tissue sealing during cell elimination is critical for barrier function.
  • Epithelial cell extrusion is a key mechanism for cell removal while preserving tissue integrity.

Purpose of the Study:

  • To detail the cellular remodeling events during epithelial cell extrusion.
  • To explore variations in cell extrusion across different tissues and organisms.
  • To discuss the broader implications of cell extrusion in tissue morphogenesis and disease.

Main Methods:

  • Review of cellular remodeling processes during cell extrusion.
  • Analysis of cytoskeletal and cell-junctional changes.
  • Comparative examination across various epithelial systems.

Main Results:

  • Cell extrusion involves coordinated remodeling of the cytoskeleton and cell-cell junctions.
  • These changes affect mechanical coupling and mechanotransduction.
  • Variations exist in extrusion mechanisms across different tissues and organisms.

Conclusions:

  • Epithelial cell extrusion is a complex yet minimalist morphogenetic process.
  • It ensures tissue barrier integrity during cell turnover.
  • Understanding cell extrusion is vital for insights into tissue development, repair, and diseases like cancer.