BLOOD AND CYTOGENETIC MARKERS IN EXPERIMENTAL BURNS AND THEIR TREATMENT WITH [CU(LCF3)2] AND [СU(ADM)(PPH3)2]PF6

The search for effective agents in the treatment of burn injuries is one of the urgent problems of combustiology. Over the past years, the incidence of burn injury has been continuously increasing worldwide. In burn injury, there is not only local tissue damage in the area of action of the offending agent, but also a complex reaction of the body to the resulting damage in the form of burn disease. Summing up the karyotyping results under thermal burn, it can be concluded that the intraperitoneal administration of compounds Cu(LCF3)2 and [Cu(Adm)(PPh3)2]PF6 has a corrective effect on hemorheological and hemodynamic disorders occurring in thermal burn. This effect is most pronounced in the first days after correction. According to the results of karyotyping under thermal burn, it can be stated that the compound [Cu(Adm)(PPh3)2]PF6 has the most positive results, and the compound Cu(LCF3)2 was less effective. This fact is confirmed when comparing survival, cytogenetic parameters, and blood parameters after administration of these compounds. Cytogenetic abnormalities were recorded during the burn injury. When correcting [Cu(Adm)(PPh3)2]PF6, a tendency towards increased proliferation is observed both on the 15th and 30th days. The chromosomal aberrations and the number of polyploid cells were statistically significantly reduced in the group with [Cu(Adm)(PPh3)2]PF6 application relative to the pure thermal burn group in both the 15th and 30th days, indicating the beneficial effect of this copper complex on the burn.