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RIFM fragrance ingredient safety assessment, 4-isopropylphenol, CAS Registry Number 99-89-8
A M Api1, A Bartlett1, D Belsito2
1Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.
Summary
4-Isopropylphenol demonstrates a favorable safety profile, showing no genotoxicity or significant risks in repeated dose, reproductive, or skin sensitization studies. Environmental assessments confirm it is not Persistent, Bioaccumulative, and Toxic (PBT).
Area of Science:
- Toxicology and Environmental Safety Assessment
- Chemical Risk Evaluation
Background:
- Comprehensive safety evaluations are crucial for chemicals used in consumer products.
- Understanding the toxicological profile of 4-Isopropylphenol is essential for regulatory compliance and consumer safety.
Purpose of the Study:
- To evaluate the genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety of 4-Isopropylphenol.
- To determine the safety margins and potential risks associated with the current declared levels of use.
Main Methods:
- Utilized read-across data from analogous substances, p-cresol (CAS # 106-44-5) and thymol (CAS # 89-83-8).
- Assessed genotoxicity, repeated dose toxicity, and reproductive toxicity via Margin of Exposure (MOE) calculations.
- Evaluated photoirritation/photoallergenicity using UV/Vis spectra, local respiratory toxicity via Threshold of Toxicological Concern (TTC), and environmental safety using IFRA standards and PEC/PNEC ratios.
Main Results:
- 4-Isopropylphenol is not expected to be genotoxic, with MOE > 100 for repeated dose and reproductive toxicity.
- No skin sensitization concerns were identified; it is not expected to be photoirritating/photoallergenic.
- Exposure is below the TTC for local respiratory toxicity, and environmental risk quotients (PEC/PNEC) are <1, indicating no PBT concerns.
Conclusions:
- 4-Isopropylphenol presents no significant safety concerns for genotoxicity, repeated dose toxicity, reproductive toxicity, skin sensitization, photoirritation/photoallergenicity, or local respiratory toxicity at current usage levels.
- The substance is not classified as Persistent, Bioaccumulative, and Toxic (PBT), and its environmental risk is considered low.
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