Related Experiment Video
Updated: May 13, 2025

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
Current Approaches to Treat and Prevent Recurrence of Clostridioides difficile
Adam M Ressler1, Krishna Rao1, Vincent B Young2
1Department of Internal Medicine, Infectious Disease Division, University of Michigan Medicine, Ann Arbor, MI, USA.
Abstract:
Clostridioides difficile infection (CDI) and recurrent CDI (rCDI) are significant causes of morbidity and mortality. The microbiome plays a significant role in the body's defense against CDI and rCDI. Antibiotics can cause significant injury to the microbiome which leads to an increased risk of CDI and rCDI. Ongoing perturbations of the microbiome perpetuate this risk. Antibiotic treatments for CDI can kill C difficile but also can impact the microbiome. Microbiome therapeutics are effective in restoring the function of the gut microbiota and re-establishing colonization resistance. The field of microbiome therapeutics is evolving with newer, more refined, modalities in development.
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