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Computed Tomography

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...

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Single- and Multiphase CT Angiography Is Associated With Digital Subtraction Angiography Collateral Score ≥3.

Tara Srinivas¹, Dhairya A Lakhani², Aneri B Balar²

¹Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland, USA.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging

|May 14, 2025

Summary

This summary is machine-generated.

Multiphase CT angiography derived from CT perfusion (dCTA) effectively determines collateral status in acute ischemic stroke (AIS) patients with large vessel occlusions, aiding clinical decisions.

Keywords:

CTA collaterals ischemic stroke reperfusion

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Area of Science:

Neurology
Radiology
Cardiovascular Medicine

Background:

Collateral status is a key predictor of outcomes in acute ischemic stroke (AIS).
Accurate assessment of collateral circulation is crucial for guiding treatment decisions in large vessel anterior circulation AIS.

Purpose of the Study:

To evaluate the effectiveness of multiphase CT angiography derived from CT perfusion (dCTA) in assessing collateral status.
To compare dCTA-derived collateral assessment against the reference standard digital subtraction angiography (DSA) ASITN/SIR score.

Main Methods:

Retrospective analysis of 311 AIS patients undergoing mechanical thrombectomy.
Inclusion criteria: CTA-confirmed anterior circulation large vessel occlusion, CTP, and DSA collateral score.
Logistic regression used to analyze factors associated with collateral status and reperfusion.

Main Results:

dCTA and CTA Tan were significant predictors of favorable collateral status (ASITN score ≥3) in multivariate analysis.
Proximal M2 occlusion site and dCTA were independently associated with good collateral flow.
dCTA demonstrated a significant association with higher ASITN/SIR scores.

Conclusions:

dCTA is a valuable tool for assessing collateral status in AIS patients with large vessel occlusions.
dCTA findings correlate with DSA-based collateral scores, potentially improving clinical decision-making.
Further research is warranted to explore dCTA's role in predicting patient outcomes.