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Factors Affecting Nasal Discharge in Chronic Rhinosinusitis Patients
Pranav A Patel1, Ethan M Kallenberger1, Shaun A Nguyen1
1Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Female sex, CRS without polyps, prior surgery, and allergies are linked to severe postnasal discharge in chronic rhinosinusitis patients. Understanding these factors can improve symptom management.
Area of Science:
- Otolaryngology
- Rhinology
- Sinonasal Disease Research
Background:
- Nasal discharge is a key symptom of chronic rhinosinusitis (CRS), but patient descriptions vary.
- The SNOT-22 questionnaire assesses four distinct nasal discharge symptoms.
- Identifying factors influencing discharge severity is crucial for effective patient care.
Purpose of the Study:
- To investigate patient-specific factors associated with the severity of nasal drainage in CRS.
- To analyze demographic and comorbid condition influences on postnasal discharge (PND) severity.
Main Methods:
- Cross-sectional analysis of 1020 CRS patients from a prospective, multi-institutional cohort study.
- Utilized SNOT-22 scores, defining severe symptoms as scores ≥3.
- Performed bivariate odds ratio calculations and multivariate regression analysis.
Main Results:
- Postnasal discharge (PND) was the most severe symptom reported (average SNOT-22 score 2.98).
- 67.3% of patients reported severe PND.
- Severe PND associated with female sex (OR=2.0), CRS without nasal polyps (OR=1.5), prior endoscopic sinus surgery (ESS) (OR=1.5), and allergies (OR=1.4).
Conclusions:
- Patients with CRS experience more severe symptoms related to PND.
- Female sex, CRS without nasal polyps, prior ESS, and allergies are significant predictors of severe PND.
- This study is the first to link demographic and comorbid factors to PND severity in CRS.
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