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Updated: Jun 14, 2025
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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
EDA Complex-Mediated Aerobic Three-Component CDC Reactions of Quinoxalinones under Visible-Light Irradiation
Xiaoyuan Wan1, Richang Wen1, Yi Fang1
1College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, China.
Abstract:
A visible-light-induced Minisci-type three-component aerobic cross-dehydrogenative coupling (CDC) reaction of quinoxalinones with styrenes and acetophenones is described. The catalytic electron donor-acceptor (EDA) complexation of quinoxalinones with TMSCl is found to be the key for oxygen activation, which initiates the oxidative radical formation of acetophenones under photocatalyst-free conditions. This three-component protocol provides facile and efficient access to structurally valuable highly functionalized quinoxalinones with generally high chemoselectivity and moderate to good yields.
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