Biomedical Treatment Nanomotors Based on the Intestinal Axis: Current Challenges

Area of Science:

• Gastroenterology and Nanomedicine

Background:

• The gut microbiome plays a critical role in the intestinal axis, influencing physiological and pathological processes.
• Imbalances in gut microbial homeostasis are characteristic of inflammatory bowel disease (IBD).
• Gut microbes and their metabolites communicate with organs along the intestinal axis, impacting disease progression.

Purpose of the Study:

• To review the application of nanomotors in treating IBD.
• To explore the challenges and future directions of nanomotor-based therapies for IBD targeting the intestinal axis.

Main Methods:

• Literature review focusing on nanomotor applications in IBD treatment.
• Analysis of nanomotor capabilities in active targeting and energy conversion.
• Examination of nanomotor advantages over traditional drug delivery for intestinal axis-based therapies.

Main Results:

• Nanomotors demonstrate active targeting and self-propulsion, overcoming passive drug delivery limitations.
• Their selectivity and initiative offer potential solutions for IBD therapies targeting the intestinal axis.
• Current nanomotor applications in IBD treatment face specific difficulties that require further investigation.

Conclusions:

• Nanomotors represent a novel therapeutic strategy for IBD by enabling targeted interventions along the intestinal axis.
• Further research is needed to address current difficulties and fully realize the potential of nanomotor-based IBD treatments.
• Nanomotor technology holds promise for advancing IBD management through innovative approaches to the intestinal axis.