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Updated: Sep 19, 2025
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Pd, Rh-Catalyzed Regioselective Hydroformylation of Olefins with Formic Acid and Its Salts
Wenlong Ren1, Yang Liu1, Jintao Ou1
1Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Institute of Natural and Synthetic Organic Chemistry, Changzhou University, Changzhou 213164, China.
Abstract:
Efficient Pd- or Rh-catalyzed regioselective hydroformylation processes with HCO2Na/Ac2O or HCO2H/Ac2O are described. The linear aldehydes can be obtained in good yields with high l/b ratios. These two systems (HCO2Na/Ac2O vs HCO2H/Ac2O) give generally comparable results with their own advantages for certain substrates. In general, the Pd-catalyzed formylation reaction gives higher regioselectivities for vinyl arenes, while the Rh-catalyzed process gives higher regioselectivities for certain alkyl terminal olefins. All of these formylation processes are simple to operate and provide complementary methods for the synthesis of aldehydes from olefins.
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