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Updated: Sep 8, 2025

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
Published on: May 24, 2020
Thrombosis and Coagulopathy
Marzia Savi1, Gregory Hawryluk2
1Department of Intensive Care, Neurosciences and Trauma Critical Care Unit, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, UK.
Abstract:
Effective anticoagulation management is crucial for balancing thromboembolism and hemorrhage risks in patients with traumatic brain injury (TBI) and spinal cord injury (SCI). A systematic review from January 1984 to August 2024 highlights a growing preference for prothrombin complex concentrate (PCC) as the primary reversal agent, with limited evidence on idarucizumab for dabigatran. Most studies show that 4F-PCC improves mortality and hemostatic efficacy, facilitating faster surgical interventions. The lack of large clinical trials remains a significant gap, limiting the development of standardized protocols. Increasing use of viscoelastic assays for assessing residual anticoagulant activity offers potential for more personalized treatment strategies.
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