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Updated: Sep 17, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Pathology of Melanoma: New Concepts (2025 Update)
Justine Galambus1, Ciaran Smythe1, Clay J Cockerell2
1Department of Dermatology, Lake Granbury Medical Center, University of North Texas, 2100 Research Row Suite 100, Dallas, TX 75235, USA.
None:
The American Cancer Society estimates that nearly 105,000 new cases of invasive melanoma of the skin and over 107,000 new cases of melanoma in situ will be diagnosed in the United States in 2025. In this same year, over 8,400 deaths from melanoma of the skin are predicted. Among non-Hispanic white individuals, the overall lifetime risk of developing invasive melanoma is 1-in-29 for male individuals and 1-in-40 for female individuals. Among this population, overall 5 year survival rates have improved from 82% in 1975 to 1997 to 94% in 2014 to 2020. As expected, disease that is only local at diagnosis confers an excellent greater than 99% 5 year survival, whereas melanoma that has metastasized regionally or distant confers only a 75% or 35% 5 year survival, respectively.
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