Related Experiment Video
Updated: Jul 2, 2026
10:26
Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
12.3K
Association Between Salivary Circular RNAs Expression and Periodontal Disease Status
Pingping Han1,2, Kexin Jiao1, Peter Mark Bartold2
1The University of Queensland, School of Dentistry, Epigenetics Nanodiagnostic and Therapeutic Group, Center for Orofacial Regeneration, Rehabilitation and Reconstruction (COR3), Brisbane, Queensland, Australia.
Journal of Periodontal Research
|July 1, 2025
Summary
Salivary circular RNAs, such as circRUNX2 and circMMP9, show promise as non-invasive biomarkers for diagnosing periodontitis. These biomarkers can also help distinguish the rate of disease progression, improving diagnostic tools.
Area of Science:
- Biochemistry
- Molecular Biology
- Periodontology
Background:
- Periodontitis is a prevalent inflammatory disease affecting the gums and supporting bone.
- Current diagnostic methods for periodontitis may be invasive or lack precision in assessing disease progression.
- Circular RNAs (circRNAs) are emerging as stable molecules with potential diagnostic applications.
Purpose of the Study:
- To investigate the potential of salivary circRNAs as non-invasive biomarkers for periodontitis.
- To evaluate specific circRNAs, hsa_circ_0003563 (circRUNX2) and hsa_circ_0001161 (circMMP9), for diagnostic and prognostic value in periodontitis.
Main Methods:
- Analysis of salivary samples to quantify levels of specific circRNAs.
- Correlation of circRNA levels with clinical parameters of periodontitis severity and progression.
Main Results:
- Salivary circRUNX2 and circMMP9 were identified as potential biomarkers for periodontitis.
- These circRNAs demonstrated potential in distinguishing different rates of periodontitis disease progression.
Conclusions:
- Salivary circRNAs, specifically circRUNX2 and circMMP9, offer a promising non-invasive approach for periodontitis diagnosis.
- These biomarkers may aid in monitoring disease progression, leading to improved periodontal care.
