Unveiling dickkopf-1 in periodontitis progression- A review

Periodontitis is a chronic bacterial infection causing tissue damage, bone loss and tooth mobility and thus, impacting quality of life. It is influenced by factors like plaque, genetics and immune response, driving inflammation and tissue destruction. Dickkopf-1 inhibits the wingless-related integration site (Wnt) signalling pathway, reducing osteoblast activity and promoting osteoclast formation, leading to bone resorption. Neutralizing Dickkopf-1 activity may facilitate bone regeneration, suggesting its potential as a target for periodontitis treatment. Therefore, it is of interest to review the role of Dickkopf-1 in periodontitis for understanding its impact on alveolar bone resorption highlighting its therapeutic potential in improving alveolar bone health.