Related Experiment Video
Updated: May 6, 2026

Efficient Production and Purification of Recombinant Murine Kindlin-3 from Insect Cells for Biophysical Studies
Published on: March 19, 2014
Collectins and Ficolins
Hajra Gupta1, Ann Mary Joseph2, Mughair Abdul Aziz3
1Department of Innate Immunity, ICMR-NIRRCH, Mumbai, India.
Abstract:
Protein-carbohydrate interactions are utilized by the immune system for several defense activities. Collectins and ficolins have a key role in maintaining the balance of surfactants in the lungs and supporting the immune system in the lungs, respectively. This chapter provides an extensive description of two soluble pattern recognition receptors (PRRs), collectins and ficolins. It covers their structure, specificity for binding to certain ligands, biological functions along with initiating immune response by various mechanisms, their genetic characteristics, associations with various diseases, and their potential for use in therapy and diagnosis. The potential of collectins as diagnostic markers and therapeutic agents in diverse malignancies for their antitumorigenic effects has also been investigated. These findings have greatly enhanced our understanding of the innate immune system's previously overlooked specificity and effectiveness.
More Related Videos
Related Concept Videos
Cytoskeletal Linker Proteins - Plakins
Cytoskeletal Accessory Proteins
Formation of Higher-order Actin Filaments
The high-order actin...
Mechanism of Filopodia Formation
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Fibril-associated Collagen
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Selectins

