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Updated: Sep 16, 2025

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Synthesis of Furan-Tethered Benzocyclobutenes via Protonic Acid-Catalyzed 1,4-Sulfinate Migration-Annulation
Ziwei Li1,2, Jingyi Li1, Jing Feng1
1School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Xiasha West Higher Education District, Hangzhou 310018, P. R. China.
Abstract:
A protonic acid-catalyzed cascade of conjugated enynones was realized for synthesizing multisubstituted furans containing benzocyclobutene with high yields and simple procedures. Employing inexpensive sulfanilic acid as a catalyst, this method features a key 1,4-sulfinate migration and avoids the use of transition metal catalysts. Substrates that are unreactive under metal-mediated catalysis are applicable due to proton transfer processes. Accordingly, this strategy provides an efficient complement to metal carbene-mediated migration-annulation strategies.
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