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Updated: Sep 15, 2025

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

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Published on: January 13, 2019

Transcriptomic Changes in Mouse Lung Tissue after a Long-Term Space Flight.

D A Yakubets¹, Yu V Rudimova¹, L B Buravkova²

¹Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.

Bulletin of Experimental Biology and Medicine

|July 18, 2025

Summary

This summary is machine-generated.

Long-term spaceflight alters gene expression in mouse lungs, with some olfactory genes unexpectedly increasing and protein folding/circadian rhythm genes decreasing. Lung cells show low gravity sensitivity and high adaptability.

Keywords:

differential gene expression lung tissue microgravity space flight

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Last Updated: Sep 15, 2025

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Published on: October 27, 2020

Area of Science:

Space biology
Molecular biology
Genomics

Background:

Spaceflight induces significant physiological adaptations across multiple organ systems.
Understanding molecular mechanisms, particularly transcriptional changes, is crucial for elucidating these adaptations to microgravity.

Purpose of the Study:

To investigate the transcriptomic profile of mouse lung tissue following long-term spaceflight.
To identify specific genes and pathways affected by prolonged exposure to weightlessness/microgravity.

Main Methods:

Analysis of mouse lung tissue obtained from a long-term space mission.
Transcriptomic profiling to identify differentially expressed genes.

Main Results:

Identified 45 differentially expressed genes in lung tissue.
Observed "ectopic" upregulation of G-protein-coupled olfactory and vomeronasal receptor genes.
Found downregulation of genes involved in protein folding and circadian rhythm regulation.

Conclusions:

Lung cells exhibit minimal sensitivity to gravity.
Mouse lung tissue demonstrates a high adaptive potential during prolonged spaceflight.
Transcriptional shifts provide insights into cellular adaptation mechanisms in space.