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Updated: Sep 14, 2025

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
Published on: February 24, 2023
Commiphoralactone A: A Hetero-Hybridized Sesquiterpene from Commiphora Sap against Depression That Targets
Yun-Yun Liu1, Wei-Fen Li1, Jia-Wang Liu1
1Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, P. R. China.
Abstract:
Commiphoralactones A (1) and B (2), two sesquiterpene dimers, were isolated from the sap of Commiphora trees, and their structures were characterized by spectroscopic and computational approaches. 1 and 2 represent eudesmane-type and lactonic-type acyclic side chain sesquiterpenes, respectively, formed via [4 + 2] addition featuring a 6/6/6/5 ring system. A potential biosynthetic pathway for 1 and 2 is discussed. Compound 1 exhibits a dose-dependent antidepressant effect in a lipopolysaccharide-induced rodent model. This study showcased a paradigm for discovering an in vivo effect using minor natural products.
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