Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.2K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.2K
X-linked Traits01:19

X-linked Traits

55.2K
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
55.2K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

6.5K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retinal Histology and Anatomical Landmarks.

Advances in experimental medicine and biology·2025
Same author

Fluorescein Angiography.

Advances in experimental medicine and biology·2025
Same author

Optical Coherence Tomography.

Advances in experimental medicine and biology·2025
Same author

Fundus Autofluorescence.

Advances in experimental medicine and biology·2025
Same author

Electrooculography.

Advances in experimental medicine and biology·2025
Same author

Glossary of Relevant Genetic and Molecular/Cell Biology.

Advances in experimental medicine and biology·2025
Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026
Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026
Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026
Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026
Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026
Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Sep 8, 2025

A Rhodopsin Transport Assay by High-Content Imaging Analysis
12:11

A Rhodopsin Transport Assay by High-Content Imaging Analysis

Published on: January 16, 2019

6.6K

X-Linked Retinitis Pigmentosa.

Stephen H Tsang1, Tarun Sharma2

  • 1Department of Ophthalmology, Columbia University, New York, NY, USA. sht2@cumc.columbia.edu.

Advances in Experimental Medicine and Biology
|July 30, 2025
PubMed
Summary
This summary is machine-generated.

X-linked retinitis pigmentosa (XLRP) is a severe inherited retinal disease. It represents a significant portion of all retinitis pigmentosa cases globally.

Keywords:
Retinitis pigmentosaX-linked

More Related Videos

Isolation of Retinal Pigment Epithelial Cells from Guinea Pig Eyes
05:06

Isolation of Retinal Pigment Epithelial Cells from Guinea Pig Eyes

Published on: May 9, 2023

2.3K
A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration
09:24

A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration

Published on: March 10, 2023

1.8K

Related Experiment Videos

Last Updated: Sep 8, 2025

A Rhodopsin Transport Assay by High-Content Imaging Analysis
12:11

A Rhodopsin Transport Assay by High-Content Imaging Analysis

Published on: January 16, 2019

6.6K
Isolation of Retinal Pigment Epithelial Cells from Guinea Pig Eyes
05:06

Isolation of Retinal Pigment Epithelial Cells from Guinea Pig Eyes

Published on: May 9, 2023

2.3K
A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration
09:24

A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration

Published on: March 10, 2023

1.8K

Area of Science:

  • Ophthalmology
  • Genetics
  • Molecular Biology

Background:

  • X-linked retinitis pigmentosa (XLRP) is a severe inherited retinal disease.
  • It accounts for 6-20% of all retinitis pigmentosa (RP) cases.
  • XLRP prevalence is approximately 10% in the United States and 25% in England.

Purpose of the Study:

  • To provide a comprehensive overview of X-linked retinitis pigmentosa.
  • To highlight the genetic basis and clinical manifestations of XLRP.
  • To discuss the current understanding and potential therapeutic strategies for XLRP.

Main Methods:

  • Literature review of existing studies on XLRP.
  • Analysis of epidemiological data on RP prevalence.
  • Synthesis of genetic and clinical findings related to XLRP.

Main Results:

  • XLRP is a leading cause of inherited blindness.
  • Genetic mutations on the X chromosome are responsible for XLRP.
  • Significant regional variations in XLRP prevalence exist.

Conclusions:

  • XLRP poses a substantial burden of visual impairment.
  • Further research into XLRP pathogenesis is crucial.
  • Development of targeted therapies for XLRP is a priority.