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Updated: Sep 13, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
ASSOCIATION BETWEEN MICROALBUMINURIA AND THYROID DYSFUNCTION COMPARED TO DIABETIC KIDNEY DISEASE PROGRESSION IN TYPE
S Hussein1, D Al Ayoub1, R Abdulrahman1
11Medical Laboratory Sciences Department, College of Health Sciences, Gulf Medical University, Ajman, UAE.
Introduction And Objective:
Microalbuminuria is an early marker of diabetic nephropathy and cardiovascular risk in type 2 diabetes mellitus (T2DM), thyroid dysfunction influences glucose metabolism and renal function, raise the risk of complications in type 2 diabetes. This study aims to evaluate the association between microalbuminuria levels and Thyroid hormonal profile compared with the progression risk of diabetic kidney disease in type 2 diabetes patients.
Methodology:
A cross-sectional comparative study, the target population consisted of 303 males and females aged between 22 to 75 years, the study participants were grouped into diabetics 203 and non-diabetics 100. The blood sample was collected from diabetic patients and used for measured FBG, HbA1c, TSH, FT4 and FT3 levels. For microalbumin urine test, A urine sample taken from the patients in sterile urine container. Beckman coulter DXC700 AU analyzer used for FBG, HbA1c and microalbumin by turbidimetric method and for TSH, FT3, FT4 used Beckman coulter DXI 800 analyzers.
Results:
Microalbuminuria levels were significantly elevated in the diabetic patients (153.7±4.7) compared to the non-diabetic group (76.3±3.8), (P=0.006). TSH levels significantly in the diabetic patients (6.9±1.4) compared to the non-diabetic group (2.8±0.7, P=0.017), FT3 levels showed insignificant difference between diabetic (4.6±1.9) and non-diabetic patients (4.5±1.8) (P=0.352) and FT4 levels significantly raised in diabetic patients (14.8±5.1) compared to non-diabetic participants (13.1±3.4) (P=0.003). The results revealed significant association between thyroid hormonal profile and the severity of microalbuminuria (P=0.031), also the results demonstrated strong relationships between thyroid hormones levels and the severity of microalbuminuria by comparing minimum, maximum, and mean values. A significant association was observed in the scatter matrix correlation between TSH, FT3, FT4, and microalbuminuria levels, with a p-value<0.05.
Conclusion:
In conclusion, observed significant correlations between thyroid hormone levels and microalbuminuria revealed that was associated with the progression of diabetic kidney complications.
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