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Updated: Sep 13, 2025

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
08:00

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation

Published on: October 4, 2024

685

A new angle on RGS protein modulation

David L Roman1

  • 1Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, Holden Comprehensive Cancer Center, Iowa Neuroscience Institute - University of Iowa, Iowa City, IA, USA.

Trends in Pharmacological Sciences
|August 2, 2025
PubMed
Summary

Researchers developed a new method to stabilize Regulator of G-protein signaling 2 (RGS2) by preventing its degradation. This approach shifts focus from inhibiting RGS protein function to modulating G-protein-coupled receptor signaling pathways.

Keywords:
RGShigh throughput screeningubiquitin

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