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Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
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Regenerative Dentistry: Applications of Bioactive Materials in Dentin-Pulp Complex
Soner Sismanoglu1, Vasfiye Işık2, Pınar Ercal3
1Faculty of Dentistry, Department of Restorative Dentistry, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Advances in Experimental Medicine and Biology
|August 20, 2025
Summary
Tissue engineering offers vital pulp therapies (VPTs) as a regenerative alternative to root canal treatments. Innovations in stem cells, growth factors, and biomaterials promise enhanced dental pulp regeneration and tooth repair.
Area of Science:
- Dentistry
- Regenerative Medicine
- Biomaterials Science
Background:
- Dental pulp is crucial for tooth health but vulnerable to damage, leading to pulp loss.
- Conventional root canal treatments often result in pulp devitalization.
- Tissue-engineered vital pulp therapies (VPTs) aim to preserve pulp vitality and promote natural healing.
Purpose of the Study:
- To explore the potential of tissue engineering in regenerating dental pulp.
- To highlight the roles of stem cells, growth factors, scaffolds, and bioactive materials in pulp regeneration.
- To discuss emerging innovations like 3D bioprinting and exosome-based therapies.
Main Methods:
- Utilizing dental pulp-derived stem cells for their differentiation potential into odontoblast-like cells.
- Employing bioactive scaffolds releasing growth factors to enhance pulp tissue healing.
- Investigating novel biomaterials such as calcium silicate-based materials and bioactive glasses.
Main Results:
- Stem cells, growth factors, and bioactive scaffolds show significant promise in promoting dentin production and pulp regeneration.
- Innovative materials like calcium silicate and bioactive glasses facilitate restorative dentin formation.
- Tissue engineering approaches offer a path towards restoring dentin-pulp structure and function.
Conclusions:
- Tissue engineering holds significant potential for dental pulp regeneration, offering alternatives to conventional treatments.
- Further research and interdisciplinary collaboration are essential to address challenges in clinical application, long-term efficacy, and cost-effectiveness.
- Advancements in regenerative dentistry, including 3D bioprinting and exosome therapies, are paving the way for future innovations.
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