Recent Advances in Handheld and Robotic Bioprinting Approach for Tissue Engineering

Area of Science:

• Biomedical Engineering
• Tissue Engineering
• Regenerative Medicine

Background:

• 3D bioprinting is revolutionizing tissue engineering for patient-specific tissues.
• Translating 3D bioprinting from laboratory to clinical practice remains a significant challenge.

Purpose of the Study:

• To review the latest advancements in in situ 3D bioprinting for tissue regeneration.
• To analyze handheld and robotic arm-assisted bioprinting techniques for clinical translation.

Main Methods:

• Systematic review of current literature on in situ 3D bioprinting.
• Examination of handheld and robotic arm-assisted bioprinting systems.
• Analysis of biomaterial, engineering, and clinical integration aspects.

Main Results:

• Handheld and robotic arm-assisted bioprinting enable direct reconstruction of damaged tissues in situ.
• These advanced techniques offer adaptability and precise anatomical matching.
• Key challenges include bioink formulation, mechanical property optimization, and extracellular matrix mimicry.

Conclusions:

• In situ 3D bioprinting holds significant potential for clinical tissue regeneration.
• Addressing current limitations in bioinks and fabrication is crucial for successful bench-to-bedside translation.
• Further research and development are needed to fully realize the clinical applications of this technology.