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Balloons in Benign Prostatic Hyperplasia: Will They Float? A Comprehensive Review of Prostatic Balloon Prostatoplasty
Alexis E Te1, Steven A Kaplan1
1Department of Urology, The Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1272, New York, NY 10029, USA.
The Urologic Clinics of North America
|October 17, 2025
Summary
Drug-coated balloon dilation (Optilume) offers a durable solution for benign prostatic hyperplasia (BPH), preventing regrowth and improving symptoms. This minimally invasive procedure preserves sexual function and enhances urinary flow rates effectively.
Area of Science:
- Urology
- Minimally Invasive Therapies
- Medical Device Technology
Background:
- Benign prostatic hyperplasia (BPH) is a common condition affecting aging men, leading to lower urinary tract symptoms.
- Traditional BPH treatments have limitations, including potential side effects and the need for retreatment.
- Paclitaxel-coated balloon technology aims to overcome limitations of earlier dilation methods by inhibiting tissue regrowth.
Purpose of the Study:
- To explore the evolution and clinical evidence of drug-coated balloon dilation (Optilume) for BPH treatment.
- To analyze the positioning of Optilume within the current BPH treatment landscape.
- To evaluate the efficacy and safety of Optilume in improving BPH symptoms and urinary flow.
Main Methods:
- Review of clinical evidence and available data on drug-coated balloon dilation (Optilume) for BPH.
- Analysis of patient outcomes, including International Prostate Symptom Score (IPSS) improvement and retreatment rates.
- Comparison of Optilume with existing BPH treatment modalities.
Main Results:
- Durable symptom improvement observed, with 67.5% of patients achieving ≥30% IPSS improvement at 24 months without retreatment.
- Significant improvement in urinary flow rates demonstrated.
- The procedure preserves sexual function, a key consideration for BPH patients.
Conclusions:
- Drug-coated balloon dilation (Optilume) represents a significant advancement in BPH management.
- The technology offers durable symptom relief and improved urinary function with a favorable safety profile.
- Optilume provides an effective, office-based treatment option that preserves sexual function, positioning it favorably within the BPH treatment spectrum.
