Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview Of Cell Separation And Isolation01:20

Overview Of Cell Separation And Isolation

Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Monoclonal antibodies against human TMPRSS2 prevent infection by any SARS-CoV-2 variant.

iScience·2025
Same author

Development of Animal Models for Preclinical Safety Studies.

Advances in experimental medicine and biology·2025
Same author

Cell and gene therapy approvals in Asia: regulatory landscape, access and affordability.

Cytotherapy·2025
Same author

Assessment of Polyhexamethylene Biguanide Hydrochloride-Resistance in Purpureocillium Species and Development PCR-based Detection Method.

Medical mycology journal·2025
Same author

The role of IL-4+ memory T cells in SARS-CoV-2 booster vaccination.

International immunology·2025
Same author

An exploratory cluster-randomized controlled trial on mindfulness yoga's effectiveness in school-refusing children: reductions in SCAS-C physical injury fears and pulse rate.

Frontiers in human neuroscience·2024

Related Experiment Video

Updated: May 11, 2026

A High-throughput Automated Platform for the Development of Manufacturing Cell Lines for Protein Therapeutics
07:48

A High-throughput Automated Platform for the Development of Manufacturing Cell Lines for Protein Therapeutics

Published on: September 22, 2011

22.7K

Development of Automated Systems for Cell Therapy.

Takako Yamamoto1, Masaki Hosoya2, Shin Kawamata3,4

  • 1Kobe University Graduate School of Science, Technology and Innovation, Kobe, Japan.

Advances in Experimental Medicine and Biology
|October 24, 2025
PubMed
Summary

Automated cell manufacturing systems enhance efficiency and reduce errors. A quality by design (QbD) approach with in-process monitoring enables product quality assurance, streamlining cell therapy production.

Keywords:
2-AAAAutomationCCPsCQAsDigitizationElectric batch recordGlycolytic pathwayIn-process monitoringKynurenineOXPHOSPharma 4.0QTPPQbDQuality by designWarburg effecteBR

More Related Videos

Automated Counterflow Centrifugal System for Small-Scale Cell Processing
04:49

Automated Counterflow Centrifugal System for Small-Scale Cell Processing

Published on: December 12, 2019

9.7K
Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow
09:03

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

Published on: March 17, 2023

2.6K

Related Experiment Videos

Last Updated: May 11, 2026

A High-throughput Automated Platform for the Development of Manufacturing Cell Lines for Protein Therapeutics
07:48

A High-throughput Automated Platform for the Development of Manufacturing Cell Lines for Protein Therapeutics

Published on: September 22, 2011

22.7K
Automated Counterflow Centrifugal System for Small-Scale Cell Processing
04:49

Automated Counterflow Centrifugal System for Small-Scale Cell Processing

Published on: December 12, 2019

9.7K
Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow
09:03

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

Published on: March 17, 2023

2.6K

Area of Science:

  • Biotechnology
  • Process Engineering
  • Cell Therapy Manufacturing

Background:

  • Automated systems are crucial for cell therapy manufacturing efficiency and error reduction.
  • Current robotic systems (Pharma 3.0) lack process visualization and inventory control, necessitating end-product verification.
  • Simple robotic mimicry does not drive innovation in cell manufacturing.

Purpose of the Study:

  • To present a quality by design (QbD)-based automated closed-type cell manufacturing system.
  • To integrate in-process monitoring for real-time quality assurance.
  • To eliminate the post-manufacturing verification step and facilitate industrialization.

Main Methods:

  • Development of a closed-type automated cell manufacturing system.
  • Implementation of quality by design (QbD) principles.
  • Integration of in-process monitoring and data logging.

Main Results:

  • The system assures product quality by manufacturing as designed, eliminating the need for pre-shipment verification.
  • In-process monitoring provides real-time quality control and process visualization.
  • The automated system supports the industrialization and dissemination of cell therapy.

Conclusions:

  • A QbD-based automated system with in-process monitoring revolutionizes cell therapy manufacturing.
  • This approach ensures product quality and streamlines the production process.
  • It is a key step towards the industrialization and widespread adoption of cell therapies.