Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

7.7K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.7K
The Tumor Microenvironment02:17

The Tumor Microenvironment

7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
Skin Cancer01:30

Skin Cancer

5.7K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consensus Guidelines for Staging and Surveillance Imaging in Cutaneous Squamous Cell Carcinoma.

JAMA dermatology·2026
Same author

Addressing Biases in Analysis of Time of Infusion: NCI/SWOG Trial S1404 Among Participants With High-Risk Resectable Melanoma Who Received Adjuvant Anti-PD-1 Therapy.

JCO oncology practice·2026
Same author

Melanoma: Cutaneous, Version 2.2026, NCCN Clinical Practice Guidelines In Oncology.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

TIL cell therapy in HIV positive patient with metastatic melanoma: case report.

Frontiers in oncology·2026
Same author

Association Between Serum Cortisol Levels and Variant Angina.

Korean circulation journal·2026
Same author

HSR26-247: Real-World Quality of Life in Patients Treated With Cemiplimab for Advanced Cutaneous Squamous Cell Carcinoma: Results of CemiplimAb Survivorship Epidemiology (CASE) Study.

Journal of the National Comprehensive Cancer Network : JNCCN·2026

Related Experiment Video

Updated: Jan 11, 2026

Merkel Cell Polyomavirus Infection and Detection
13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

10.3K

Contemporary Management of Merkel Cell Carcinoma.

Catherine S Valukas1, Sunandana Chandra2, Jaehyuk Choi3

  • 1Department of Surgery, Surgical Outcomes and Quality Improvement Center, Northwestern University Feinberg School of Medicine, 676 North Saint Clair Street, Suite 2320, Chicago, IL 60611, USA.

Hematology/Oncology Clinics of North America
|November 12, 2025
PubMed
Summary

Merkel cell carcinoma, a rare skin cancer, is aggressive and often diagnosed late. Newer immunotherapy treatments show promise for metastatic cases, with ongoing trials for resected disease.

Keywords:
Cutaneous neuroendocrine tumorMerkel cell carcinomaMerkel cell polyomavirusNonmelanoma skin cancer

More Related Videos

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

16.5K
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

10.9K

Related Experiment Videos

Last Updated: Jan 11, 2026

Merkel Cell Polyomavirus Infection and Detection
13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

10.3K
A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

16.5K
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

10.9K

Area of Science:

  • Oncology
  • Dermatology
  • Virology

Background:

  • Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin tumor.
  • Risk factors include ultraviolet exposure, Merkel cell polyomavirus infection, and immunosuppression.
  • MCC is often diagnosed at advanced stages with poor prognosis.

Purpose of the Study:

  • To summarize the current understanding and treatment landscape of Merkel cell carcinoma.
  • To highlight recent advancements in managing metastatic MCC.
  • To discuss ongoing research in early-stage disease.

Main Methods:

  • Literature review of Merkel cell carcinoma epidemiology, risk factors, and treatment modalities.
  • Analysis of recent clinical trial data on immunotherapy for MCC.
  • Synthesis of current treatment guidelines for resected and metastatic MCC.

Main Results:

  • Initial stage MCC treatment involves resection and radiotherapy.
  • Metastatic MCC has a poor prognosis with limited response to chemotherapy.
  • Programmed cell death protein 1 (PD-1) axis inhibitors have improved outcomes in metastatic MCC.
  • Clinical trials are evaluating PD-1 inhibitors in resected MCC.

Conclusions:

  • Despite treatment advances, metastatic Merkel cell carcinoma remains challenging.
  • Immunotherapy, particularly PD-1 inhibitors, represents a significant breakthrough.
  • Further research is crucial for optimizing treatment strategies in both early and advanced stages of MCC.