Contemporary Multimodal Management of Primary Retroperitoneal Sarcomas

Retroperitoneal sarcoma is composed of a heterogeneous group of mesenchymal neoplasms that has poor prognosis. Although surgery remains the mainstay of treatment, achieving complete surgical resection with adequate margins is challenging, given anatomic constraints. Evidence on the use of adjunctive treatment modalities for retroperitoneal sarcoma is sparse, with the treatment rationale often based on data extrapolated from other soft tissue sarcomas. Recent studies demonstrate some benefits of neoadjuvant radiotherapy for histologic subtypes with high locoregional recurrence rates. Ongoing studies are evaluating various novel adjunctive treatment modalities.