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Fusion Is the Optimal Treatment of Lumbar Spondylolisthesis: The Modified Minimally Invasive Interbody Selection
Abraham Dada1, Niall Buckley1, Marc Prablek2
1Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Room M-779, San Francisco, CA 94143, USA.
Neurosurgery Clinics of North America
|November 20, 2025
Summary
For symptomatic lumbar spondylolisthesis, surgical fusion is preferred over decompression alone in North America. Evidence supports fusion for L4-5 and L5-S1 conditions, utilizing various techniques.
Area of Science:
- Orthopedics
- Neurosurgery
- Spinal Surgery
Background:
- Lumbar spondylolisthesis is a common cause of low back pain.
- Degenerative and isthmic subtypes typically affect L4-5 and L5-S1 levels.
- Surgical options include decompression alone or with fusion.
Purpose of the Study:
- To review the evidence supporting surgical treatments for lumbar spondylolisthesis.
- To compare decompression alone versus decompression with fusion.
- To highlight preferred fusion techniques in North American populations.
Main Methods:
- Review of evidence from studies like SpineCORe and the SLIP trial.
- Analysis of outcomes for decompression versus fusion.
- Categorization of available fusion techniques.
Main Results:
- Growing evidence supports fusion as the preferred surgical option for lumbar spondylolisthesis in North America.
- Decompression with fusion shows favorable outcomes compared to decompression alone.
- Posterolateral fusion and minimally invasive interbody fusions are established techniques.
Conclusions:
- Surgical fusion is recommended for symptomatic lumbar spondylolisthesis in North American populations.
- Various fusion techniques, including minimally invasive options, are available.
- Further research may refine treatment selection based on specific subtypes and patient factors.

