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    This study introduces a novel MRI and magnetic positioning system for real-time motion compensation. It achieves sub-millimeter accuracy, enabling artifact-free MRI for dynamic interventions.

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    Area of Science:

    • Medical Imaging
    • Biomedical Engineering
    • Robotics

    Background:

    • Magnetic Resonance Imaging (MRI) is crucial for diagnostics but struggles with real-time motion compensation.
    • Existing systems often introduce artifacts or lack precision for dynamic scenarios.
    • High-accuracy tracking is essential for MRI-guided interventions.

    Purpose of the Study:

    • To develop and validate a co-designed MRI and magnetic positioning system for real-time dynamic motion compensation.
    • To achieve sub-millimeter tracking accuracy while maintaining diagnostic image quality.
    • To enable artifact-free MRI imaging during dynamic patient motion.

    Main Methods:

    • System-level co-design of MRI and magnetic localization systems with a custom receiver IC.
    • Time-division multiplexing with FPGA-synchronized blanking for spectral isolation.
    • Dynamic calibration algorithm fusing magnetic tracking and multi-frame MRI data.
    • MRI-optimized Levenberg-Marquardt algorithm with dynamic beacon weighting.

    Main Results:

    • Median positioning accuracy of 0.66 mm across a large field-of-view (40×40×50 cm³).
    • Reduced spatial blur radius by 40% using a dynamic calibration algorithm.
    • Improved localization accuracy by 53% compared to conventional algorithms.
    • Artifact-free MRI imaging achieved in dynamic scenarios.

    Conclusions:

    • The co-designed system enables real-time imaging of non-autonomous and respiratory motion.
    • This technology represents a paradigm shift for MRI-guided interventions requiring high precision.
    • The system bridges the gap between high-precision tracking and artifact-free MRI.