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Updated: Jan 8, 2026

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Selectfluor-Mediated C(sp3)-S Bond Cleavage for the Synthesis of Aryl Sulfinate Esters
Long Liu1, Naichen Zhang1, Yicong Ge1
1Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, China.
Abstract:
A Selectfluor-mediated protocol for the direct synthesis of aryl sulfinate esters from aryl alkyl thioethers is reported. This reaction is initiated by Selectfluor-promoted C(sp3)-S bond cleavage and engages the substrate in a formal stepwise oxidation process to furnish aryl sulfinate esters. This method operates under mild conditions, tolerates diverse functionalities, and provides efficient access to synthetically valuable sulfinate scaffolds.
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