Selective Reductive Elimination from Pd(IV)-Enabled Dual C-H Alkylation
Qiongqiong Zhu1, Xiang Zuo1, Dongdong Tu1
1School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China.
Abstract:
Reductive elimination is a fundamental step in organometallic transformations, yet controlling the selectivity between two (hetero)aryl groups during this process from a Pd(IV) center remains a significant challenge. Herein, we report selective reductive elimination from C(aryl),C(pyrrolyl)-Pd(IV) complexes. The alkylated Pd(IV) complexes undergo selective reductive elimination at pyrrolyl groups. Building on this, we developed dual C-H alkylation reactions, yielding dialkylated pyrrole products.
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