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Bioactive Glass Modified by Sonochemistry Improves Peri-Implant Bone Repair in Ovariectomized Rats.

Marcelly Braga Gomes¹, Nathália Dantas Duarte^2,3, Gabriel Mulinari-Santos¹

¹Department of Basic Sciences, School of Dentistry (FOA-UNESP), São Paulo State University "Júlio de Mesquita Filho", Araçatuba 16015-050, SP, Brazil.

Biomimetics (Basel, Switzerland)

|December 24, 2025

Summary

This summary is machine-generated.

Sonochemically modified bioactive glass enhanced bone healing in estrogen-deficient rats, improving implant stability and bone structure. This approach shows promise for improving peri-implant repair in compromised bone environments.

Keywords:

biocompatible materials bone regeneration dental implants osseointegration osteoporosis sonochemical technique sonochemistry

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Area of Science:

Biomaterials Science
Regenerative Medicine
Skeletal Biology

Background:

Estrogen deficiency, a cause of osteoporosis, impairs bone mineral density and peri-implant healing.
Sonochemistry offers particle reduction to enhance regenerative outcomes in compromised bone.
The effect of sonochemistry on bone formation in estrogen-deficient models is not well understood.

Purpose of the Study:

To evaluate sonochemically modified biomaterials for improving peri-implant repair in ovariectomized rats.
To assess the impact of sonication on bone regeneration and implant stability in an estrogen-deficient state.

Main Methods:

Fifty ovariectomized rats received tibial peri-implant defects.
Groups included blood clot (CLOT), Biogran® (BGN), sonicated Biogran® (BGS), Bio-Oss® (BON), and sonicated Bio-Oss® (BOS).
Analyses at 28 days post-implantation included removal torque, microcomputed tomography (micro-CT), and confocal microscopy.

Main Results:

Sonochemically modified Biogran® (BGS) showed the highest removal torque (6.28 Ncm).
Micro-CT revealed higher bone volume fraction (BV/TV) in CLOT (8.07%) and BOS (6.47%) compared to other groups, with BGS showing 6.02%.
BGS significantly increased trabecular number (Tb.N) (1.11 mm⁻¹) compared to BGN (0.69 mm⁻¹).

Conclusions:

Sonochemically modified bioactive glass significantly improves mechanical stability and trabecular microarchitecture in estrogen-deficient bone.
This modification enhances peri-implant repair under compromised bone conditions.
Further research is needed to optimize sonication parameters and assess translational applicability.