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Potentially Problematic Research Practices in a Study on Ketamine for Pediatric Depression

Martin Plöderl1, Joanna Moncrieff2,3

  • 1Center for Inpatient Psychotherapy and Crisis Intervention, University Clinic for Psychiatry/Psychotherapy/Psychosomatics, Paracelsus Medical University, Salzburg, Austria.

The American Journal of Psychiatry
|January 1, 2026
PubMed
Summary

No abstract available in PubMed .

Keywords:
Child/Adolescent PsychiatryDepressive DisordersKetamine/EsketamineSuicide and Self-Harm

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Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
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