Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

4.9K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
4.9K
A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk09:04

A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk

9.9K
We describe a 3D human extracellular matrix-adipocyte in vitro culture system that permits dissection of the roles of the matrix and adipocytes in contributing to adipose tissue metabolic...
9.9K
Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies05:25

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

2.9K
The present protocol provides instructional information for using tobacco hornworm Manduca sexta in cannabinoid research. The method described here includes all necessary supplies and protocols to monitor physiological and behavioral changes of the insect model in response to cannabidiol (CBD)...
2.9K
LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism06:04

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

11.7K
Here we show isolated human platelets can be used as an accessible ex vivo model to study metabolic adaptations in response to the complex I inhibitor rotenone. This approach employs isotopic tracing and relative quantification by liquid chromatography-mass spectrometry and can be applied to a variety of study...
11.7K
Realistic Membrane Modeling Using Complex Lipid Mixtures in Simulation Studies07:31

Realistic Membrane Modeling Using Complex Lipid Mixtures in Simulation Studies

3.1K
Membrane lipid diversity in structure and composition is an important contributor to cellular processes and can be a marker of disease. Molecular dynamics simulations allow us to study membranes and their interactions with biomolecules at atomistic resolution. Here, we provide a protocol to build, run, and analyze complex membrane...
3.1K
Multimodal Optical Imaging Platform for Studying Cellular Metabolism04:47

Multimodal Optical Imaging Platform for Studying Cellular Metabolism

1.0K
Utilizing a multimodal platform combining label-free optical imaging modalities, we have developed a protocol for visualizing and quantifying cellular dynamics and metabolism. Through imaging via multiphoton fluorescence, second harmonic generation, and stimulated Raman scattering microscopy, we can generate a holistic overview of the cellular and molecular...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Androgen levels and experimental pain sensitivity in healthy young adolescent girls.

Pain·2025
Same author

The role of androgens on experimental pain sensitivity: a systemic review and meta-analysis.

Pain reports·2025
Same author

The role of androgens in migraine pathophysiology.

Neurobiology of pain (Cambridge, Mass.)·2024
Same author

Insect Models to Study Human Lipid Metabolism Disorders.

Advances in experimental medicine and biology·2024
Same author

Polygenic adaptation to overnutrition reveals a role for cholinergic signaling in longevity.

bioRxiv : the preprint server for biology·2023
Same author

Inclusion of Thyroid Nodule Location in American College of Radiology TI-RADS Scoring: Impact on System Performance.

AJR. American journal of roentgenology·2021

Related Experiment Video

Updated: Jan 20, 2026

A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk
09:04

A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk

Published on: November 7, 2019

9.9K

Insect Models to Study Human Lipid Metabolism Disorders.

Thomas B Rundell1, Thomas J Baranski2

  • 1Department of Biological Sciences, Binghamton University, Binghamton, NY, USA.

Advances in Experimental Medicine and Biology
|January 19, 2026
PubMed
Summary

Insect models like Drosophila melanogaster are crucial for understanding complex lipid metabolism disorders, such as obesity. These models help unravel disease mechanisms and validate large-scale genetic studies, advancing metabolic disease research.

Keywords:
DrosophilaFatty acid beta oxidationInsect modelsLipid disordersLipid metabolismLipid transportObesity

More Related Videos

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies
05:25

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Published on: December 29, 2021

2.9K
LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism
06:04

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

11.7K

Related Experiment Videos

Last Updated: Jan 20, 2026

A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk
09:04

A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk

Published on: November 7, 2019

9.9K
Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies
05:25

Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

Published on: December 29, 2021

2.9K
LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism
06:04

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

11.7K

Area of Science:

  • Metabolic research
  • Genetics
  • Model organism research

Background:

  • Lipid metabolism disorders, including obesity, are significant global health challenges affecting over a third of the population in industrialized nations.
  • The underlying mechanisms of metabolic disease development are not yet fully understood.
  • Insect models provide a powerful system for studying conserved biological processes.

Purpose of the Study:

  • To explore the advancements and utility of insect models, specifically Drosophila melanogaster, in studying lipid metabolism disorders.
  • To highlight the role of Drosophila melanogaster in understanding conserved lipid metabolism and its associated pathologies.
  • To identify future research opportunities in the field of insect model-based metabolic disease research.

Main Methods:

  • Utilizing Drosophila melanogaster as a model organism to investigate conserved lipid metabolism.
  • Leveraging the extensive genetic tools available in Drosophila melanogaster for systematic examination of metabolic pathways.
  • Employing Drosophila melanogaster to validate findings from genome-wide association studies and other high-throughput approaches.

Main Results:

  • Drosophila melanogaster has significantly contributed to the understanding of metabolic diseases over several decades.
  • The genetic tractability of Drosophila melanogaster allows for detailed mechanistic studies of lipid metabolism.
  • This model system is effective in validating results from large-scale genetic analyses.

Conclusions:

  • Insect models, particularly Drosophila melanogaster, are invaluable tools for dissecting the complexities of lipid metabolism disorders.
  • Continued use of Drosophila melanogaster will accelerate the discovery of novel therapeutic targets for metabolic diseases.
  • Future research should further exploit insect models to address critical gaps in our knowledge of metabolic health and disease.