Related Experiment Video
Updated: Jan 30, 2026
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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Spatiotemporal Co-occurrence Patterns of Periodontitis and Oral Cancer: A Global Risk Factor and Network Analysis
Yu Xia1, Jukun Song2
1Department of Oral Medicine, Guizhou Provincial People's Hospital, Guiyang, China.
International Dental Journal
|January 28, 2026
Summary
Periodontal disease is far more common globally than oral cancer, with overlapping risk factors like tobacco use. Tailored prevention strategies are crucial for reducing the burden of both conditions.
Area of Science:
- Epidemiology
- Global Health
- Oral Health
Background:
- Periodontal disease and oral cancer share risk factors and may exhibit co-occurrence patterns.
- Understanding these patterns is essential for public health interventions.
Purpose of the Study:
- To characterize global co-occurrence patterns of periodontal disease and oral cancer.
- To identify shared and condition-specific risk factors using Global Burden of Disease (GBD) 2021 data.
Main Methods:
- Analysis of adult incidence (≥25 years) and 68 risk factors across 204 countries (1990-2021).
- Classification of countries by incidence quartiles (concordant, periodontal-dominant, oral-cancer-dominant).
- Application of Shapley Additive Explanations (SHAP) modelling, negative binomial regression, network analysis, and Granger causality testing.
Main Results:
- In 2021, periodontitis incidence (1740.92/100,000) vastly exceeded oral cancer incidence (8.97/100,000).
- Significant geographic clustering of high-burden countries in South/Southeast Asia.
- Key risk factors identified: tobacco chewing, iron deficiency, and high alcohol use for oral cancer; high systolic blood pressure, lead exposure, and processed meat for periodontitis.
Conclusions:
- Periodontal disease and oral cancer show distinct yet overlapping global distributions.
- Shared exposures like tobacco and pollutants contribute to comorbidity.
- Integrated primary care targeting modifiable risks can reduce the overall disease burden.
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