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Updated: Feb 19, 2026

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Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
Published on: April 12, 2024
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High-speed quantitative X-ray multi-contrast imaging with deep learning based modulated pattern analysis
Zhi Qiao1, Yudong Yao1, Hongyu Chen1
1Center of Transformative Science, ShanghaiTech University, Shanghai 201210, China.
Journal of Synchrotron Radiation
|February 17, 2026
Summary
Enhanced Scanning Pattern-based Imaging Neural Network (ESPINNet) offers faster, high-resolution X-ray imaging. This advanced AI tool improves multi-contrast visualization for materials and bio-samples in real-time.
Area of Science:
- Physics
- Materials Science
- Biomedical Imaging
Background:
- X-ray multi-contrast imaging (absorption, phase, dark-field) enables non-destructive visualization.
- Low efficiency in X-ray pattern analysis limits high-resolution, in situ imaging applications.
Purpose of the Study:
- Introduce the Enhanced Scanning Pattern-based Imaging Neural Network (ESPINNet) for high-speed, high-resolution quantitative imaging.
- Enhance the capabilities of previous neural networks by enabling dark-field image generation.
Main Methods:
- Leveraging scanning patterns for improved resolution and measurement precision.
- Utilizing a neural network architecture (ESPINNet) adaptable to various modulation patterns (sandpaper, coded masks, gratings).
Main Results:
- ESPINNet achieves faster data collection compared to correlation-based methods (XSVT, UMPA).
- Demonstrates balanced performance in resolution and speed, requiring fewer scanning images.
- Enables real-time 2D and 3D multi-contrast imaging.
Conclusions:
- ESPINNet is a transformative solution for high-speed, in situ X-ray imaging.
- Broad applicability in materials science and biomedical research due to its adaptability and enhanced capabilities.
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