Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

21.4K
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
21.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond language: generative artificial intelligence as a general computing model for medicine.

The Lancet. Digital health·2026
Same author

Instrumentation Digital Twins in PET and SPECT Imaging: Current Status, Challenges, and Future Directions.

Computational and structural biotechnology journal·2026
Same author

Reassurance-Focused First-Trimester Euploidy Screening With Machine Learning.

Prenatal diagnosis·2026
Same author

Machine learning-assisted event classification in cadmium zinc telluride positron emission tomography detectors leveraging entanglement-informed angular correlations.

Scientific reports·2025
Same author

Toward Integrated Clinical-Computational Nuclear Medicine.

PET clinics·2025
Same author

Response to Letter to the Editor.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology·2025
Same journal

Poisoning the Genome: Targeted Backdoor Attacks on DNA Foundation Models.

ArXiv·2026
Same journal

Mechanistic mathematical model of the in vitro infection dynamics of Bunyamwera and Batai viruses including MOI-dependent shortening of the eclipse phase.

ArXiv·2026
Same journal

AI-Driven Lumped-Element Modeling of Human Respiratory System for Studying Voice Mechanics.

ArXiv·2026
Same journal

Beyond Algorithms: Conceptual Innovation in Medical Imaging AI.

ArXiv·2026
Same journal

Feynman Kac Reweighted Schrödinger Bridge Matching for Surface-Based Tau PET Harmonization.

ArXiv·2026
Same journal

Agentic Discovery of Non-Canonical Antimicrobial Peptides with AMPGAN v3.

ArXiv·2026
See all related articles

Related Experiment Video

Updated: Feb 24, 2026

Whole-cell Super-Resolution Imaging via DNA-PAINT on a Spinning Disk Confocal with Optical Photon Reassignment
07:12

Whole-cell Super-Resolution Imaging via DNA-PAINT on a Spinning Disk Confocal with Optical Photon Reassignment

Published on: January 6, 2026

313

Maximum-Likelihood--Based Position Decoding of Laser Processed Converging Pixel CsI: Tl Detectors for High-Resolution

Xi Zhang, Arkadiusz Sitek, Lisa Blackberg

    Arxiv
    |February 23, 2026
    PubMed
    Summary
    This summary is machine-generated.

    This study presents a new method for creating high-resolution cesium iodide (CsI: Tl) detectors for single photon emission computed tomography (SPECT). The novel converging-pixel design and advanced algorithms improve SPECT imaging performance.

    More Related Videos

    Direct Imaging of Laser-driven Ultrafast Molecular Rotation
    10:52

    Direct Imaging of Laser-driven Ultrafast Molecular Rotation

    Published on: February 4, 2017

    10.3K
    Infrared Degenerate Four-wave Mixing with Upconversion Detection for Quantitative Gas Sensing
    10:42

    Infrared Degenerate Four-wave Mixing with Upconversion Detection for Quantitative Gas Sensing

    Published on: March 22, 2019

    6.6K

    Related Experiment Videos

    Last Updated: Feb 24, 2026

    Whole-cell Super-Resolution Imaging via DNA-PAINT on a Spinning Disk Confocal with Optical Photon Reassignment
    07:12

    Whole-cell Super-Resolution Imaging via DNA-PAINT on a Spinning Disk Confocal with Optical Photon Reassignment

    Published on: January 6, 2026

    313
    Direct Imaging of Laser-driven Ultrafast Molecular Rotation
    10:52

    Direct Imaging of Laser-driven Ultrafast Molecular Rotation

    Published on: February 4, 2017

    10.3K
    Infrared Degenerate Four-wave Mixing with Upconversion Detection for Quantitative Gas Sensing
    10:42

    Infrared Degenerate Four-wave Mixing with Upconversion Detection for Quantitative Gas Sensing

    Published on: March 22, 2019

    6.6K

    Area of Science:

    • Medical Physics
    • Nuclear Medicine
    • Materials Science

    Background:

    • High spatial resolution is crucial for Single Photon Emission Computed Tomography (SPECT) imaging.
    • Previous Laser Induced Optical Barrier (LIOB) methods achieved high resolution and yield in CsI: Tl detectors.
    • Extending LIOB to a converging-pixel architecture offers potential for improved SPECT detector performance.

    Purpose of the Study:

    • To demonstrate the feasibility of a novel converging-pixel CsI: Tl detector fabrication technique for SPECT.
    • To evaluate the performance of this new architecture using advanced decoding algorithms.
    • To assess the potential for developing next-generation high-performance SPECT detectors.

    Main Methods:

    • Fabrication of a CsI: Tl crystal array with a converging-pixel architecture (1.6x1.6 mm2 entrance, 2x2 mm2 photodetector side).
    • Implementation of Center of Gravity (CoG) and Maximum Likelihood (ML) based decoding algorithms for interaction localization.
    • Utilizing a custom four-axis motion platform for precise beam delivery and data acquisition.

    Main Results:

    • Achieved an energy resolution of 11.79+/-0.53% in collimated experiments.
    • Demonstrated a position localization accuracy of 1.00+/-0.42 mm using nearest neighbor interpolation.
    • Validated the performance of the converging-pixel design with statistical decoding algorithms.

    Conclusions:

    • The novel converging-pixel CsI: Tl detector architecture is feasible for SPECT applications.
    • Combining this architecture with statistical decoding algorithms significantly enhances SPECT detector performance.
    • This approach represents a promising pathway for developing advanced, high-performance SPECT systems.