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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
Circular RNAs as emerging regulators of mitochondrial function and disease
Mehrzad Esmaeili Niasan1, Soudeh Ghafouri-Fard2
1Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:
Circular RNAs (circRNAs) are a class of covalently closed, non-coding RNAs that have emerged as regulators of gene expression and cellular homeostasis. Accumulating evidence shows that circRNAs are involved in the regulation of mitochondrial function, energy metabolism, and stress responses. Dysregulation of circRNAs has been linked to a wide range of mitochondrial-associated diseases, including neurodegenerative disorders, metabolic syndromes, cardiovascular diseases, and cancers. This review summarizes current knowledge on mitochondrial-related circRNAs, their biogenesis, molecular mechanisms, and pathophysiological roles, with a focus on their potential as diagnostic biomarkers and therapeutic targets.
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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