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Related Concept Videos

Positron Emission Tomography01:29

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Related Experiment Video

Updated: Apr 17, 2026

PET/CT With [68Ga]-NOTA-FAP-2286 for Imaging of Tendon Injuries in Rat Achilles Tendon Injury Models
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18 F-NaF PET/CT in "Shin Splint" Syndrome.

Yacine El Yaagoubi1, Caroline Prunier-Aesch, Laurent Philippe

  • 1Department of Nuclear Medicine, Vinci Clinic, Tours, France.

Clinical Nuclear Medicine
|April 15, 2026
PubMed
Summary

18F-NaF PET/CT effectively diagnosed shin splint syndrome (medial tibial stress syndrome) in a runner with lower limb pain. This imaging technique shows promise as an alternative to SPECT/CT for diagnosing MTSS.

Keywords:
MTSSPET/CTmedial tibial stress syndrome“shin splint” syndrome

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Area of Science:

  • Nuclear medicine
  • Radiology
  • Sports medicine

Background:

  • Medial tibial stress syndrome (MTSS), commonly known as shin splints, is a frequent cause of exercise-induced lower limb pain in athletes.
  • Accurate diagnosis of MTSS is crucial for timely management and prevention of further injury.

Purpose of the Study:

  • To evaluate the utility of 18F-NaF PET/CT in diagnosing shin splint syndrome (MTSS).
  • To assess 18F-NaF PET/CT as a potential alternative to SPECT/CT for MTSS diagnosis.

Main Methods:

  • A case study involving a 28-year-old female runner presenting with bilateral lower limb and pelvic pain.
  • 18F-NaF PET/CT imaging was performed to investigate the cause of pain.
  • Clinical assessment included evaluating the patient's training regimen and response to reduced intensity.

Main Results:

  • 18F-NaF PET/CT revealed diffuse longitudinal uptake along the posteromedial cortical bone of both tibias.
  • The CT component showed no abnormalities, but the PET findings were highly suggestive of MTSS.
  • The patient experienced significant pain reduction after decreasing training intensity.

Conclusions:

  • 18F-NaF PET/CT imaging can be a valuable tool for diagnosing shin splint syndrome (MTSS).
  • This modality may serve as a viable alternative to SPECT/CT, particularly during shortages of molybdenum, a key component for Technetium-99m production.
  • The findings highlight the role of advanced imaging in sports medicine and the management of overuse injuries.