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Updated: May 5, 2026
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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Microbial Shifts After Sleeve Gastrectomy: The Gut-Oral Axis, Periodontal Outcomes, and Competing Oral Risks
Felicia Gabriela Beresescu1, Razvan Marius Ion2,3,4, Adriana-Stela Crisan5,6
1Faculty of Dental Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mureș, 540139 Targu Mureș, Romania.
Biomedicines
|May 4, 2026
Summary
Sleeve gastrectomy may improve some periodontal inflammation markers, but structural changes are unclear. The gut-oral axis link to periodontitis after surgery needs more research.
Area of Science:
- Bariatric Surgery
- Periodontology
- Microbiome Research
- Gut-Oral Axis
Background:
- Severe obesity links to inflammation, dysglycemia, and periodontitis risk.
- Sleeve gastrectomy (SG) improves weight and metabolism but oral health outcomes vary.
- Understanding postoperative oral health changes is crucial.
Purpose of the Study:
- Synthesize evidence on periodontal outcomes after SG.
- Investigate oral and gut microbiome changes post-SG.
- Explore mechanistic pathways linking surgery to the gut-oral axis.
Main Methods:
- Structured narrative review using major scientific databases.
- Searches complemented by citation chaining.
- Evidence categorized into clinical, microbiome, and mechanistic streams.
Main Results:
- Some studies show improvements in bleeding on probing and gingival indices with SG.
- Clinical attachment level changes are mixed; long-term structural data is limited.
- Gut microbiome shifts and bile acid changes are consistently reported, but the gut-oral link is indirect.
Conclusions:
- The sleeve gastrectomy-gut-oral axis-periodontal pathway is a plausible hypothesis.
- Current evidence for periodontal benefits is mainly from small observational studies.
- Benefits are more evident for inflammatory rather than structural periodontal endpoints.
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