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Related Concept Videos

The DNA Replication Fork01:02

The DNA Replication Fork

An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication forks, one in...
The DNA Replication Fork01:02

The DNA Replication Fork

An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication forks, one in...
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
The Replisome03:01

The Replisome

DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with the...
DNA Replication02:40

DNA Replication

DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication uses a large number of...
DNA Packaging00:58

DNA Packaging

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Updated: Jun 26, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

DNA origami snaps into place.

Kerstin Göpfrich1,2

  • 1Heidelberg University, Center for Molecular Biology of Heidelberg University (ZMBH), Berliner Str. 45. Heidelberg, Germany.

Science Robotics
|June 24, 2026
PubMed
Summary
This summary is machine-generated.

A new DNA origami switch uses electricity to perform logic operations, enabling programmable control for molecular machines. This innovation advances the field of molecular robotics with reliable, switchable components.

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Last Updated: Jun 26, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
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Published on: September 27, 2019

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09:17

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Published on: March 5, 2019

Area of Science:

  • Biochemistry
  • Nanotechnology
  • Molecular Engineering

Background:

  • DNA origami enables the precise nanoscale assembly of DNA structures.
  • Molecular robotics requires reliable components for programmable control and computation.

Purpose of the Study:

  • To develop an electrically controlled DNA origami structure that functions as a switch.
  • To demonstrate the potential of this switch for programmable logic operations in molecular robotics.

Main Methods:

  • Design and fabrication of a DNA origami nanostructure with a snap-through mechanism.
  • Application of electrical fields to induce and control the snap-through transition.
  • Characterization of the switch's response and logic gate functionality.

Main Results:

  • The DNA origami structure successfully exhibited an electrically controlled snap-through behavior.
  • The switch demonstrated robust and programmable logic operations, including AND and OR gates.
  • The system showed high fidelity and stability under applied electrical stimuli.

Conclusions:

  • Electrically controlled DNA origami switches offer a promising platform for building complex molecular machines.
  • This work establishes a foundation for programmable logic and computation at the molecular level.
  • The developed switch represents a significant advancement in the field of molecular robotics and nanotechnology.