Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
Defenses Against Pathogens and Herbivores02:26

Defenses Against Pathogens and Herbivores

Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
Antimicrobial Proteins01:23

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Surface Membrane Barriers01:18

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Inhibitors of Gram-positive Cell Wall Synthesis01:23

Inhibitors of Gram-positive Cell Wall Synthesis

Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biologic Improvement of Skin: Pathways and Activation of Stem Cells, Growth Factors, and Peptides.

Facial plastic surgery clinics of North America·2026
Same author

Nutritional Biologics for Skin and Hair.

Facial plastic surgery clinics of North America·2026
Same author

Development of a Core Outcome Domain Set for Facial Aging.

JAMA dermatology·2026
Same author

Novel Application of a Chimeric Upper Gracilis Free Flap for Facial Reanimation with Reconstruction.

Facial plastic surgery & aesthetic medicine·2026
Same author

Evolution of Facial Plastic Surgery Global Surgery Outreach in the Context of International Conflict and the COVID-19 Pandemic.

Facial plastic surgery & aesthetic medicine·2026
Same author

Endoscopic Brow Lifting: A 35-Year Experience and Lessons Learned.

Facial plastic surgery clinics of North America·2025
Same journal

Healing from Within: Biologics in Facial Plastic Surgery.

Facial plastic surgery clinics of North America·2026
Same journal

The Natural Healing Force Within Each of Us.

Facial plastic surgery clinics of North America·2026
Same journal

US Food and Drug Administration and Regulation Issues for Biologics: The Sands Are Shifting.

Facial plastic surgery clinics of North America·2026
Same journal

Direct Injection of Stem Cells and Differentiated Cells: European Experience and Dubai Perspective.

Facial plastic surgery clinics of North America·2026
Same journal

A New Frontier of Cosmetic Technology: Modified mRNA for Personalized Applications.

Facial plastic surgery clinics of North America·2026
Same journal

Photobiomodulation and Biological Pathways in Skin Regeneration and Rejuvenation: Light and Biological Activation of Skin Improvement.

Facial plastic surgery clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Jul 4, 2026

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group
07:49

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group

Published on: August 16, 2017

Defensins.

Sunder Gidumal1, Francis Reyes Orozco1, Gabrielle Cahill1

  • 1Department of Head and Neck Surgery, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.

Facial Plastic Surgery Clinics of North America
|July 2, 2026
PubMed
Summary
This summary is machine-generated.

Defensin peptides show promise for skin and hair rejuvenation. This review covers their potential in regenerative aesthetics, drawing from animal and human studies.

Keywords:
DefensinsHuman α-defensin 5JAK/STAT signalingLGR5+ and LGR6+ epithelial stem cellsPaneth cellsTransforming growth factor-β

More Related Videos

Live-cell Imaging of Fungal Cells to Investigate Modes of Entry and Subcellular Localization of Antifungal Plant Defensins
08:39

Live-cell Imaging of Fungal Cells to Investigate Modes of Entry and Subcellular Localization of Antifungal Plant Defensins

Published on: December 24, 2017

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Related Experiment Videos

Last Updated: Jul 4, 2026

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group
07:49

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group

Published on: August 16, 2017

Live-cell Imaging of Fungal Cells to Investigate Modes of Entry and Subcellular Localization of Antifungal Plant Defensins
08:39

Live-cell Imaging of Fungal Cells to Investigate Modes of Entry and Subcellular Localization of Antifungal Plant Defensins

Published on: December 24, 2017

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Area of Science:

  • Dermatology and Regenerative Medicine
  • Cosmeceutical Science

Background:

  • Defensin peptides are key components of the innate immune system.
  • Emerging research highlights their role beyond immunity, particularly in tissue repair and regeneration.
  • Understanding defensins is crucial for advancing regenerative aesthetic therapies.

Purpose of the Study:

  • To review the current evidence on defensin peptides for skin and hair rejuvenation.
  • To provide an evidence-based overview for clinicians on defensin therapy.
  • To explore the integration of defensins into regenerative aesthetic practices.

Main Methods:

  • Comprehensive literature review of preclinical animal models.
  • Analysis of mechanistic studies on defensin function.
  • Evaluation of human clinical trials involving alpha-defensin and beta-defensin formulations.

Main Results:

  • Defensins exhibit potential as regenerative peptides in skin and hair.
  • Evidence spans from basic science to clinical applications.
  • Safety and regulatory aspects are considered alongside efficacy.

Conclusions:

  • Defensin peptides represent a promising frontier in regenerative aesthetics.
  • Further research and clinical trials can solidify their role in aesthetic practice.
  • Defensin therapy offers a novel approach to skin and hair rejuvenation.