Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genetic Screens

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

Preventive Healthcare Services

Preventive Healthcare Services

Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:

Pharmacogenomics: Identification of New Drug Targets

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mainstreaming genetic testing in community oncology settings.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026

Same author

Impact of Population-Based Pathogenic Variant Testing on Risk-Based Breast Screening Recommendations: A Secondary Analysis of the WISDOM Study.

JAMA oncology·2026

Same author

WISDOM randomized trial comparing risk-based versus annual breast cancer screening: study cohort characteristics and design.

NPJ breast cancer·2026

Same author

Multimodality Evaluation of Regional Breast Lymph Nodes: Impact of Expected Changes in the Upcoming BI-RADS Sixth Edition.

Radiographics : a review publication of the Radiological Society of North America, Inc·2026

Same author

Patient-Based Decision Making for Opioid Prescriptions After Ambulatory Breast Operation: A Randomized Clinical Trial.

Journal of the American College of Surgeons·2026

Same author

Risk-Based vs Annual Breast Cancer Screening: The WISDOM Randomized Clinical Trial.

JAMA·2025

Search research articles

Related Experiment Video

Updated: Jul 10, 2026

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

Genetics, Screening, and Risk-reducing Interventions for Breast Cancer.

Julie Le¹, Lisa Madlensky², Tara A Retson³

¹Department of Surgery, Breast Surgery Division, UC San Diego School of Medicine, San Diego, CA, USA.

The Surgical Clinics of North America

|July 8, 2026

Summary

This review helps surgeons understand breast cancer genetics and risk assessment. It covers screening, genetic testing, and risk-reducing strategies for personalized patient care.

Keywords:

Endocrine therapy Genetics High-risk screening Risk models Risk-reducing mastectomy

Related Experiment Videos

Last Updated: Jul 10, 2026

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

Area of Science:

Oncology
Genetics
Medical Imaging

Background:

Breast cancer management requires understanding genetic predispositions.
Accurate risk assessment is crucial for effective screening and prevention.

Purpose of the Study:

To provide general surgeons with a guide to breast cancer genetics, risk assessment, and management.
To review evidence-based screening and risk-reducing strategies for diverse patient populations.

Main Methods:

Clinical review of current literature on breast cancer genetics and risk assessment models.
Evaluation of various screening modalities, including mammography, MRI, and molecular breast imaging.
Discussion of genetic testing indications, interpretation, and risk-reducing interventions.

Main Results:

Outlines risk assessment using models like Gail and Tyrer-Cuzick for average-risk and high-risk women.
Reviews benefits and limitations of supplemental diagnostic imaging in breast cancer screening.
Emphasizes individualized patient care based on mutation status and family history.

Conclusions:

Surgeons can integrate genetic knowledge into prevention, early detection, and tailored breast cancer management.
Personalized strategies incorporating genetic insights improve patient outcomes.
This review equips clinicians with tools for comprehensive breast cancer risk management.