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Synthesis and decomposition are two types of redox reactions. Synthesis means to make something, whereas decomposition means to break something. The reactions are accompanied by chemical and energy changes.
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Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
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Published on: October 15, 2019

Diversity Oriented Clicking for Modular Synthesis.

Zifei Wang1, Joshua A Homer1, Elias K Zegeye2

  • 1Cancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

Nature Reviews. Methods Primers
|July 11, 2026
PubMed
Summary
This summary is machine-generated.

Diversity Oriented Clicking (DOC) combines click chemistry and Fluoride Exchange (FEx) for rapid, biocompatible covalent bond formation. This approach accelerates drug discovery by enabling the creation of diverse compound libraries and efficient screening.

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Area of Science:

  • Synthetic chemistry
  • Medicinal chemistry
  • Chemical biology

Background:

  • Classical click reactions offer reliability but limited versatility.
  • Fluoride Exchange (FEx) chemistry utilizes selective handles (sulfur- or phosphorus-bound fluorine).
  • A need exists for integrated platforms enabling rapid, biocompatible bond formation for complex molecule synthesis.

Purpose of the Study:

  • To introduce and validate Diversity Oriented Clicking (DOC) as an integrated synthetic platform.
  • To demonstrate DOC's ability to form covalent bonds rapidly under mild, biocompatible conditions.
  • To showcase DOC's utility in generating structurally diverse compound libraries for chemical space exploration.

Main Methods:

  • Fusion of classical click chemistry principles with Fluoride Exchange (FEx) reaction mechanisms.
  • Application of DOC workflows for the synthesis of complex molecular architectures.
  • Utilizing fluorine atoms on sulfur or phosphorus as selective reaction handles.

Main Results:

  • DOC enables rapid and efficient covalent bond formation.
  • The platform operates under mild and biocompatible conditions.
  • DOC facilitates the creation of diverse compound libraries, expanding accessible chemical space.

Conclusions:

  • Diversity Oriented Clicking (DOC) represents a versatile and reliable synthetic strategy.
  • DOC significantly broadens the synthetic toolkit for constructing molecular complexity.
  • The DOC platform shows substantial promise for accelerating drug discovery, including protein function analysis and high-throughput screening.