Epigenetic alterations in Myeloid Malignancies

Epigenetic alterations have emerged as central contributors to the pathogenesis, progression, and therapeutic response in cancer, and in this particular case, which we are discussing, myeloid malignancies. Unlike genetic mutations, epigenetic changes, like DNA methylation and histone modifications, are reversible and dynamic, and this book chapter aims to provide a comprehensive overview of the fundamental principles of epigenetic regulation and explores how these mechanisms are disrupted across different myeloid malignancies. We will examine disease-specific epigenetic landscapes and highlight the key alterations that occur within myeloid malignancies and discuss how such alterations can contribute to leukemogenesis and disease progression. Altogether, this chapter emphasizes the central role of epigenetic dysregulation in shaping the biology and clinical behavior of myeloid malignancies.