Related Experiment Video
Updated: Jul 13, 2026
06:51
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
Targeting Lung Cancer Metabolism: Therapeutic Opportunities and Challenges
Catarina Freitas-Dias1,2, Cindy Mendes3,4
1iNOVA4Health, NOVA Medical School | Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Lisboa, Portugal.
Advances in Experimental Medicine and Biology
|July 11, 2026
Summary
Lung cancer metabolism is crucial for tumor growth and treatment resistance. Targeting metabolic reprogramming offers new therapeutic strategies for this leading cancer killer.
Area of Science:
- Oncology
- Cancer Metabolism
- Molecular Biology
Background:
- Lung cancer is a leading cause of cancer death globally.
- Conventional treatments like chemotherapy offer limited long-term survival.
- Targeted therapies and immunotherapies show promise but have variable efficacy.
Purpose of the Study:
- To examine metabolic reprogramming in lung cancer cells.
- To understand the role of metabolism in tumor progression and treatment resistance.
- To highlight novel therapeutic strategies targeting cancer metabolism.
Main Methods:
- Review of current literature on lung cancer metabolism.
- Analysis of metabolic alterations including glycolysis, glutaminolysis, and lipid metabolism.
- Exploration of the tumor microenvironment's influence on cancer metabolism.
Main Results:
- Lung cancer cells exhibit significant metabolic reprogramming.
- Altered metabolism impacts tumor progression, immune evasion, and therapy resistance.
- Specific metabolic pathways are critical for lung cancer survival and growth.
Conclusions:
- Cancer metabolism is a critical factor in lung cancer.
- Targeting metabolic pathways presents a promising therapeutic avenue.
- Further research into metabolic reprogramming could improve lung cancer treatment outcomes.
Related Concept Videos
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:50Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:56Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...