Related Experiment Video
Updated: Jul 13, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
Use of Nuclear Magnetic Resonance (NMR) to Study Cancer Metabolism
Catarina Freitas-Dias1,2, Luís Gafeira Gonçalves3
1NOVA Medical School | Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Lisboa, Portugal.
None:
Nuclear magnetic resonance (NMR) spectroscopy has emerged as an important tool in cancer metabolism research, providing noninvasive, quantitative, and revealing insights into tumor biochemistry. This chapter discusses a wide range of NMR applications in oncology, including biofluid metabolomics for early diagnosis and prognosis, high-resolution magic angle spinning (HR-MAS) NMR for intact tissue profiling, and stable isotope-resolved metabolomics (SIRM) for mapping metabolic fluxes. Furthermore, the use of NMR in cancer cell culture models and the transformative influence of dynamic nuclear polarization (DNP)-enhanced NMR for real-time metabolic imaging are addressed. Collectively, these techniques allow for thorough analysis of metabolic reprogramming in cancer, biomarker development, and tailored therapy strategies.
Related Concept Videos
Applications Of NMR In Biology
The...
Nuclear Magnetic Resonance (NMR): Overview
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
Atomic Nuclei: Magnetic Resonance
Magnetic Resonance Imaging
Other Nuclides: 31P, 19F, 15N NMR
While fluorine-19 and phosphorous-31 have high natural abundances (100%) and positive gyromagnetic ratios, nitrogen-15 has a low natural abundance and a negative gyromagnetic ratio. However, nitrogen-15 is still preferred over nitrogen-14 (which has a high...
NMR Spectrometers: Overview

