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An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
Dietary and Supplementation Strategies for Modulating Gut Microbiota: A Narrative Review
Natalia Ekstedt-Biskot1, Dominika Jamioł-Milc2, Klaudia Melkis2
1Department of Biochemical Science, Pomeranian Medical University in Szczecin, Broniewskiego 24, 71-460 Szczecin, Poland.
Foods (Basel, Switzerland)
|July 28, 2026
Summary
Dietary fiber, fermented foods, prebiotics, probiotics, synbiotics, and postbiotics can modulate the gut microbiota (GM) for health. However, effects are context-dependent, requiring personalized approaches for optimal gut homeostasis.
Area of Science:
- Microbiology
- Nutrition Science
- Gastroenterology
Background:
- The gut microbiota plays a crucial role in human health, influencing metabolism, immunity, and gut-brain axis communication.
- Imbalances in gut microbial composition are linked to various health conditions.
- Understanding microbiota modulation is key to developing targeted health strategies.
Purpose of the Study:
- To review current evidence on dietary and supplementation strategies for modulating the gut microbiota.
- To explore the mechanisms of action for these interventions.
- To highlight the context-dependent nature of microbiota modulation.
Main Methods:
- Narrative review of existing scientific literature.
- Focus on dietary fiber, fermented foods, prebiotics, probiotics, synbiotics, and postbiotics.
- Analysis of mechanisms including microbial composition, SCFA production, and immune responses.
Main Results:
- Dietary and supplemental strategies can influence gut microbiota composition and function.
- Mechanisms involve effects on microbial diversity, short-chain fatty acid (SCFA) production, and immune modulation.
- The efficacy of interventions is highly dependent on individual factors like baseline microbiota and health status.
Conclusions:
- Microbiota-targeted nutritional strategies show potential for supporting gut homeostasis and health outcomes.
- Effects are not universal and vary significantly between individuals.
- Future research should focus on personalized and well-controlled approaches for microbiota modulation.
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