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Updated: Sep 8, 2026
Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
A dual-recognition paper-based sensor integrating a Ru/Co nanoparticle-single-atom catalytic interface for trace
Jing Zhou1, Zhen Xu1, Xin Zhang1
1College of Chemistry and Chemical Engineering, Xinyang Key Laboratory of Functional Nanomaterials for Bioanalysis, Henan Province Key Laboratory of Utilization of Non-Metallic Mineral in the South of Henan, Xinyang Normal University, Xinyang 464000, China. gantianxynu@163.com.
Abstract:
Although there has been relatively widespread exposure to bisphenol A (BPA) in the environment and consumer products, the sensitivity and selectivity of the current electrochemical sensors are still inadequate for accurate on-site monitoring of complex samples. To fill this deficiency, we have developed a flexible, single-use paper-based sensor that combines a nanoparticle-single-atom catalytic interface with an aptamer-molecularly imprinted polymer (Apt-MIP) dual recognition layer. The electrode material, Co@RuCoCNT, is prepared from a RuCo-ZIF precursor, has Ru/Co nanoparticles and atomically dispersed Co sites anchored onto nitrogen-doped hollow carbon nanotubes, and is then vacuum-filtered onto a patterned paper electrode. An Apt-MIP film electro-assembled on the Au-decorated surface creates shape-matched cavities for BPA. A detection limit of 23 fM and two linear ranges (0.1 pM-1.0 nM and 1.0 nM-1.0 μM) have been achieved. The recovery rates of real water and food samples are between 92.7 and 103%, and it shows good selectivity for BPA analogues. This paper presents an excellent design idea for a dual-recognition sensing platform and provides strong support for developing a high-performance detection tool for endocrine-disrupting substances.
